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Tuesday, May 5, 2020 | History

3 edition of Human pulmonary function response to a controlled exposure to fine urban particulate matter found in the catalog.

Human pulmonary function response to a controlled exposure to fine urban particulate matter

Jason Alexander Datema

Human pulmonary function response to a controlled exposure to fine urban particulate matter

by Jason Alexander Datema

  • 319 Want to read
  • 23 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 1999.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination3 microfiches : negative. --
ID Numbers
Open LibraryOL19040137M
ISBN 100612459039

  Episodes occasionally occur when ambient ozone (O3) levels remain at or near ppm for more than 6 h. Small decrements In lung function have been reported following 2-h exposures to ppm O3. For short exposures to higher O3 concentrations, lung function decrements are a function of exposure duration. Thus, we investigated the hypothesis that prolonged exposure to ppm O3 Cited by: f work usually performed, and the cumulative exposure index was obtained using the results of biological monitoring. These were then used to divide the exposure group into low-exposure and high-exposure groups, and the dose–response relationships were examined for decreased lung function. For ventilation indices, we obtained the forced vital capacity (FVC), forced expiratory volume in the.

The potential health effect benchmark levels for considering the COHb estimates for the simulated at-risk populations 8 in this REA [risk assessment analysis] were identified (in section ) based on data from a well-conducted multi-center controlled human exposure study demonstrate cardiovascular effects in subjects with moderate to severe.   Emissions from a large peat fire in North Carolina in were associated with increased hospital admissions for asthma and the rate of heart failure in the exposed population. Peat fires often produce larger amounts of smoke and last longer than forest fires, however few studies have reported on their toxicity. Moreover, reliable alternatives to traditional animal toxicity testing are needed Cited by:

Fine Particulate Matter Co-Exposure Enhances Pulmonary Neutrophilic, but not Eosinophilic, Inflammation in a Murine Model of Ozone-Induced Non-Atopic Asthma. Am J Respir Crit Care Med; A ; Type: Book Chapters Status: Published Year Published: Citation: Harkema, JR Carey, SA, Wagner JG, Dintzis, SM and D Liggitt (). Air pollution is the introduction of natural or built environment.. The atmosphere is a complex natural gaseous system that is essential to support life on planet Earth. Stratospheric ozone depletion due to air pollution has been recognized as a threat to human health as well as to the Earth's ecosystems.. Indoor air pollution and urban air quality are listed as two of the world’s worst.


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Human pulmonary function response to a controlled exposure to fine urban particulate matter by Jason Alexander Datema Download PDF EPUB FB2

4 Assessment of Controlled Human Inhalation Exposure Studies at EPA and Associated Adverse Events INTRODUCTION. Controlled human inhalation exposure (CHIE) studies at the U.S. Environmental Protection Agency’s (EPA’s) Human Studies Facility in Chapel Hill, North Carolina, are focused on gaining an improved understanding of short-term physiologic and biomarker responses to criteria.

Controlled Human Inhalation-Exposure Studies at EPA addresses scientific issues and provides guidance on the conduct of CHIE studies. This report assesses the utility of CHIE studies to inform and reduce uncertainties in setting air-pollution standards to protect public health and assess whether continuation of such studies is warranted.

The pulmonary response to an inhaled particle is influenced by its deposition fraction and the site of deposition. Pulmonary response would be minimized if the particle were rapidly cleared and be more pronounced if the particle had a high residence time in the lung.

Jason Alexander Datema has written: 'Human pulmonary function response to a controlled exposure to fine urban particulate matter' Asked in Health How important is health for human being. Controlled exposure to emissions from diesel engines, a major source of TRAPs, caused acute respiratory irritation, inflammation, and adverse cardiovascular effects among human volunteers [].

Short-term exposures to TRAPs on or near roadways have been associated with increased respiratory tract inflammation, decreased lung function, and Cited by:   Air pollution is a leading cause of morbidity and mortality throughout the world, particularly in individuals with existing lung disease.

Of the most common air pollutants, particulate matter (PM) is associated with an increased risk of exacerbations and respiratory symptoms in individuals with existing lung disease, and to a lesser extent, in those without known respiratory by: Early-life exposure to smoke and aeroallergens may influence pulmonary function development in childhood: a US birth-cohort showed that exposure to second-hand smoke in early-life produce a reduction in lung function (Forced expiratory flow between 25% and 75% of forced vital capacity-FEF ) in childhood; the number of aeroallergen-positive Cited by:   Temporal association between pulmonary and systemic effects of particulate matter in healthy and cardiovascular compromised ratsUrmila P.

Kodavanti, Mette C. Schladweiler, Allen D. Ledbetter, Russ Hauser*, David C. Christiani*, John McGee, Judy R. Richards, Daniel L. CostaPulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects.

Chronic obstructive pulmonary disease (COPD) is a common airway disorder. In particular, acute exacerbations of COPD (AECOPD) can significantly reduce pulmonary function.

The majority of AECOPD episodes are attributed to infections, although environmental stress also plays a role. Increasing urbanization and associated air pollution, especially in developing countries, have Cited by: Human controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are.

Hemmingsen J, Rissler J, Lykkesfeldt J, Sallsten G, Kristiansen J, P P and Loft S () Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults, Particle and Fibre Toxicology, /s,Online publication date: 1 Cited by: Final Report: Benzene Metabolism in Rodents at Doses Relevant to Human Exposure from Urban Air EPA Grant Number: RC Subproject: this is subproject numberestablished and managed by the Center Director under grant R (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Particulate Matter Exposure in Agriculture 97 D u s t ex p o su r e in a nd n e ar f a rm f ie l d s i s o f increasing concern for human health and may soon be facing new emission regulations.

Exposure to ambient air pollution, especially to particulate matter, is a major risk factor for pulmonary diseases such as asthma, chronic bronchitis or pneumonia [1,2]. Numerous epidemiological studies indicate that long- and short-term exposure to PM10 (particulate matter with an aerodynamicCited by: An approach to assess the Particulate Matter exposure for the population living around a cement plant: A dose-response relationship for the effects of ozone on pulmonary function in humans has been derived using the concept of internal thoracic dose.

This quantity, which represents the dose of inhaled pollutant capable of reaching and. Particulate Matter and Its Impact on Human Health in Urban Settings PA, Silverman F () DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments.

Particulate Matter and Its Impact on Human Health in Urban Settings. In: Agarwal A., Gautam A., Sharma N., Singh A Cited by: 2.

Air Pollution and Health is the first fully comprehensive and current account of air pollution science and it impact on human health. It ranges in scope from meteorology, atmospheric chemistry, and particle physics to the causes and scope of allergic reactions and.

Controlled human exposure studies in the laboratory can control for potential confounders, but generally with some sacrifice of relevance to complex real-world exposures.

To control for these factors in a real-world setting, we randomized exposure to HEPA-filtered and unfiltered vehicle cabin air in a blinded, cross-over study design. On Septemthe World Trade Center collapse created an enormous urban disaster site with high levels of airborne pollutants.

First responders, rescue and recovery workers, and residents have since reported respiratory symptoms and developed pulmonary function abnormalities. Exposure to traffic-related air pollutants (TRAPs) has been associated with cardiovascular and respiratory health effects []-[].Exposure to TRAPs is highly prevalent, and for many individuals, a substantial proportion of daily exposure to TRAPs occurs during work commutes in rush-hour traffic [].Although the health effects of these short-term, intense exposures to TRAPs are not well Cited by:.

Exposure to airborne fine particulate matter (PM) carries substantial health risks, particularly for younger children (0–10 years). Epidemiological evidence indicates that children are more susceptible to PM health effects than adults.

We conducted a literature review to obtain an overview of existing knowledge regarding the correlation of exposure to short- and long-term PM Cited by: In the few controlled human exposure studies conducted in individuals with asthma or COPD, PM exposure mostly had no effect on respiratory symptoms, lung function, or pulmonary inflammation.

Available studies in healthy people also did not clearly find .Fine particulate matter (PM ) promotes heart oxidative stress (OS) and evokes anti-inflammatory responses observed by increased intracellular 70 kDa heat shock proteins (iHSP70).

Furthermore, PM increases the levels of these proteins in extracellular fluids (eHSP70), which have proinflammatory roles. We investigated whether moderate and high intensity training under exposure to low Cited by: 6.